Diversity and Evolutionary Analysis of Venom Insulin Derived from Cone Snails

Diversity and Evolutionary Analysis of Venom Insulin Derived from Cone Snails

Blog Article

Cone snails possess a diverse array of novel peptide toxins, which selectively target ion channels and receptors in the Can Cooler nervous and cardiovascular systems.These numerous novel peptide toxins are a valuable resource for future marine drug development.In this review, we compared and analyzed the sequence diversity, three-dimensional structural variations, and evolutionary aspects of venom insulin derived from different cone snail species.

The comparative analysis reveals that there are significant variations in the sequences and three-dimensional structures of venom insulins from cone snails with different feeding habits.Notably, the venom insulin of some Fridge Control Module piscivorous cone snails exhibits a greater similarity to humans and zebrafish insulins.It is important to emphasize that these venom insulins play a crucial role in the predatory strategies of these cone snails.

Furthermore, a phylogenetic tree was constructed to trace the lineage of venom insulin sequences, shedding light on the evolutionary interconnections among cone snails with diverse diets.